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Defining the boundariese1 between the 2 inflammatory muscle diseases, inclusion body myositis (IBM) and polymyositis (PM), has been a continuing endeavor for more than half a century, with implications for patient management and for understanding disease pathogenesis. PM was recognized at least by 1887,e2 remaining largely undisturbed until a first case series of 6 IBM patients with distinct pathologic (rimmed vacuoles) and clinical (distal weakness and treatment refractoriness) differences that was described in 1978.e3
Footnotes
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
See page 879
- Received July 5, 2022.
- Accepted in final form September 19, 2022.
- © 2022 American Academy of Neurology
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