Do old HLA and mitochondrial DNA variants associate with demyelination types in young patients?
Citation Manager Formats
Make Comment
See Comments
This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Predicting disease progression with biomarkers can enhance care. Two articles from the Canadian Pediatric Demyelinating Disease Network in the current issue of Neurology® consider the frequency of 2 different putative biomarkers. The investigators assessed nuclear (DRB1*1501)1 and mitochondrial (various)2 genetic variants in pediatric patients who present with acquired demyelinating syndromes. DRB1*1501 association with multiple sclerosis (MS) is confirmed, whereas associations of mitochondrial (mt)DNA polymorphisms are more ambiguous. In the present studies, samples were prospectively collected from all patients with acquired demyelinating syndromes and the genetic data were analyzed for association with conversion to MS. The results provide incremental evidence for association of these genetic variants with MS. Further, the unique ascertainment and design of these studies raise several issues, such as the putative differences between acquired demyelinating syndromes and MS, between pediatric and adult MS, and between genetic associations with susceptibility to MS (cases vs controls) vs early course of demyelinating disease (conversion to MS vs not).
The first article deals with a genetic variant, DRB1*1501, that is undoubtedly associated with MS.1 Conversion to MS occurred in 64 of 266 children with acquired demyelinating syndrome, more commonly in those with 1 or 2 DRB1*1501 alleles, as previously reported in adults with isolated demyelinating events.3 …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)
Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here
Purchase
Individual access to articles is available through the Add to Cart option on the article page. Access for 1 day (from the computer you are currently using) is US$ 39.00. Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means. The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use. Distributing copies (electronic or otherwise) of the article is not allowed.
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Dr. Dennis Bourdette and Dr. Lindsey Wooliscroft
► Watch
Related Articles
Topics Discussed
Alert Me
Recommended articles
-
Articles
Mitochondrial DNA haplogroups and mutations in children with acquired central demyelinationS. Venkateswaran, K. Zheng, M. Sacchetti et al.Neurology, February 02, 2011 -
Article
Clinical features of MS associated with Leber hereditary optic neuropathy mtDNA mutationsGerald Pfeffer, Ailbhe Burke, Patrick Yu-Wai-Man et al.Neurology, November 06, 2013 -
Articles
Rare mtDNA variants in Leber hereditary optic neuropathy families with recurrence of myoclonusC. La Morgia, A. Achilli, L. Iommarini et al.Neurology, January 23, 2008 -
Article
Mitochondrial DNA sequence variation in multiple sclerosisGregory J. Tranah, Adam Santaniello, Stacy J. Caillier et al.Neurology, July 01, 2015