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Abstract
A single morning dose of dual-release formulation was compared with a slow-release formulation of l-dopa plus benserazide in a randomized, double-blind, cross-over study in 16 fluctuating patients with PD. The mean time to “on” was shorter with the dual-release formulation (43 ± 31 minutes) than with the slow-release formulation (81 ± 39 minutes) (p < 0.001), whereas the mean time to relapse to “off” was similar for both formulations. The dual-release formulation had a significantly shorter time to reach peak concentration (tmax) and greater maximum concentration (Cmax) and area under the plasma concentration time curve (AUC0–5 h) than the slow-release formulation, whereas apparent elimination half-life (t1/2) was similar for both formulations.
- Received September 21, 2000.
- Accepted in final form January 16, 2001.
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