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The use of advanced neuroimaging techniques that identify the ischemic core and the penumbra (surrounding brain tissue that has the potential for recovery) has been critical to the success of multicenter randomized controlled trials of hyperacute therapies aimed at restoring perfusion and minimizing injury related to large vessel occlusion stroke in adults. However, in the acute setting of childhood stroke, the implementation of perfusion imaging has been hampered by developmental (age-related differences in cerebral blood flow), clinical (time to diagnosis, stroke etiology, and intracranial arteriopathy), and technical (contrast delivery in acute setting and availability of software) challenges.
Footnotes
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.
See page 512
- Received October 31, 2022.
- Accepted in final form November 30, 2022.
- © 2022 American Academy of Neurology
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