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Without currently available disease-modifying drugs to treat mild cognitive impairment (MCI) or Alzheimer disease dementia, exploring the potential of nonpharmacologic interventions to prevent cognitive decline has gained increasing attention. Promoting mentally stimulating activities may represent one such strategy to prevent or slow cognitive impairment. Indeed, multiple prospective observational studies have identified a relationship between leisure activity and the risk of incident MCI or dementia,1,2 although data about the potential protective effects of cognitive activity training in randomized controlled trials remain equivocal.3–5
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