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Methotrexate (MTX) has long been a favorite drug of rheumatologists for treating rheumatoid arthritis, inflammatory myositis, and other autoimmune diseases. Why not myasthenia gravis (MG) as well? Reports of positive results of MTX treatment of MG led to this gold standard double-blind randomized controlled trial of MTX in patients with MG. The article by Pasnoor et al.1 describes the disappointing negative results of the trial, and raises important questions about the difficulties inherent in conducting such trials in MG, and the reliability of the conclusions.
Footnotes
Study funding: No targeted funding reported.
Disclosure: The author reports no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.
- © 2016 American Academy of Neurology
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