Temozolomide induces radiologic pseudoprogression and tumor cell vanishing in oligodendroglioma
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Diagnosis of radiologic pseudoprogression remains a challenge because its radiologic pattern is often indistinguishable from tumor recurrence.1 Pseudoprogression has been attributed to radiation therapy; the role of chemotherapy in pseudoprogression is uncertain.
Acknowledgments
Acknowledgment: The authors thank Dr. Joaquin Arenas, director of Instituto de Investigación Hospital 12 de Octubre (i+12), for correcting this manuscript.
Footnotes
Author contributions: Dr. Hernandez-Lain: project conception, project organization, project execution, imaging, writing first draft, manuscript review and critique. Dr. Hilario: project conception, imaging, manuscript review and critique. Dr. Sepulveda: manuscript review and critique. Diana Cantero: project execution. Dr. Ramos: manuscript review and critique. Dr. Perez-Nuñez: project conception, imaging, manuscript review and critique.
Study funding: Supported by grant FIS-PI13/01258 from the Fondo de Investigaciones Sanitarias of the Instituto de Salud Carlos III, Ministerio de Economía y Competitividad.
Disclosure: The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.
- Received December 8, 2015.
- Accepted in final form March 24, 2016.
- © 2016 American Academy of Neurology
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