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Biomarkers for neurologic disease take many forms (e.g., genetic, biochemical, structural, and functional) and have established and emerging applications in research and clinical practice.1,2 Their potential roles include detecting preclinical disease, supporting earlier or more accurate diagnosis, defining biologically homogenous subgroups of patients, predicting treatment response, assessing prognosis, and measuring change in disease severity (table). In addition, biomarkers may offer insight into the mechanisms underlying the initiation, progression, maintenance, or remission of illness.2
Footnotes
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