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Restless legs syndrome (RLS)/Willis-Ekbom disease (WED) affects 5% to 10% of the population and occurs more frequently in women, with a family history in half of patients. RLS/WED results in sleep disruption, impaired quality of life, and reduced daytime productivity; its hallmarks include an irresistible urge to move the legs at rest, temporary relief by movement, and evening worsening. In 1945, Ekbom1 postulated that leg microvascular alterations may cause RLS/WED. However, the therapeutic advent of dopaminergic drugs shifted research focus toward analyzing brain dopamine dysregulation.2
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See page 1856
- © 2014 American Academy of Neurology
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