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Abstract
Objective: To characterize movement-related neural oscillatory activity and to clarify its neurophysiologic role in paroxysmal kinesigenic dyskinesia (PKD).
Methods: We recorded neuromagnetic event-related desynchronization (ERD) and event-related synchronization (ERS) activities in response to a self-paced finger-lifting task in 16 patients with PKD and 17 healthy controls.
Results: The amplitude of α-ERD was comparable between the healthy controls and patients with PKD, whereas either the contralateral or ipsilateral β-ERS was decreased. The peak latency of contralateral β-ERS was delayed in patients with PKD. Patients with less frequent dyskinetic attacks demonstrated a larger ipsilateral β-ERS. Moreover, some patients with PKD revealed a lesser degree of contralateral preponderance of β-ERS generation.
Conclusions: The present data imply a decreased postmovement inhibition of motor cortex in patients with PKD, and the inhibitory function in the contralateral hemisphere is more affected than that in the ipsilateral hemisphere.
GLOSSARY
- ERD=
- event-related desynchronization;
- ERS=
- event-related synchronization;
- MEG=
- magnetoencephalographic;
- PKD=
- paroxysmal kinesigenic dyskinesia
Footnotes
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
Supplemental data at www.neurology.org
- Received January 3, 2013.
- Accepted in final form April 9, 2013.
- © 2013 American Academy of Neurology
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