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The pathogenesis of Parkinson disease (PD) remains elusive. In the 1960s, the loss of dopamine neurons in the substantia nigra was linked to the etiology of PD.1 This finding paved the way for the development of dopaminergic therapy to alleviate some of the symptoms of PD. Despite intensive research, however, the cellular mechanisms that lead to degeneration of dopaminergic cells in PD remain poorly understood.
Footnotes
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- © 2013 American Academy of Neurology
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