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To the Editor:
Labate et al.1 analyzed the frequency of mesial temporal abnormalities observed on brain MRIs of healthy subjects compared to patients with mesial temporal lobe epilepsy (MTLE). In an accompanying editorial, Drs. Cendes and Cascino2 discuss the clinical relevance of hippocampal sclerosis (HS) signs in subjects who undergo brain MRI for reasons other than epilepsy.
As the editorialists stated, clinicians should carefully assess and interpret neuroradiologic findings in the proper clinical context.2 MTLE due to HS is the most common epileptic syndrome and, if medically refractory, is a progressive disorder.2 This form of epilepsy has been traditionally regarded as an acquired disorder with a minimal genetic component.3 Recently, several pedigrees …
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