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Abstract
There is growing evidence in the scientific literature for shared risk and overlapping disease mechanisms in the development of cancer and Parkinson disease (PD). This association has recently been highlighted with respect to melanoma and PD. Therefore, we review and discuss the literature concerning this unexplained link. A striking overlap is observed in the tyrosine and l-dopa biosynthetic pathways suggesting a common disease mechanism associated with these 2 heterogeneous disorders that warrants further investigation.
Footnotes
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Study funding: Supported by the Medical Research Council UK (H.H.) and the Reta Lila Weston Institute (C.P.R.). This work was undertaken at University College London Hospitals/University College London, which received a proportion of funding from the Department of Health's National Institute for Health Research Biomedical Research Centers funding scheme.
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- PD
- Parkinson disease
- Received March 18, 2010.
- Accepted July 6, 2010.
- Copyright © 2010 by AAN Enterprises, Inc.
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