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As clinicians with active Parkinson disease (PD) practices, we took publication of the Attenuation of Disease Progression with Azilect Given Once-daily (ADAGIO) study results very seriously. Should rasagiline be prescribed to all patients with PD? After carefully considering this and other relevant trials, we concluded that there are insufficient data to support this practice. This parallels the scenario that played out 2 decades ago relating to investigation of another MAO-B inhibitor, selegiline.1,2
Our interpretation differs substantially from that of our colleagues, Drs. Olanow and Rascol. They argue that the ADAGIO statistical comparisons seemingly make other analyses “inappropriate” and “an …
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