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Voltage sensor charge loss accounts for most cases of hypokalemic periodic paralysis
The authors identified CACNA1S mutations in 64 of 83 cases of hypokalemic periodic paralysis. Of the remaining 19 cases examined, mutations in SCN4A or other CACNA1S S4 segments were found in 10, including three novel changes and the first mutations in channel domains I (SCN4A) and III (CACNA1S).
See p. 1544; Editorial, p. 1540
Donepezil treatment of patients with MCI: A 48-week randomized, placebo-controlled trial
This study of 821 patients with amnestic MCI found that treated individuals improved more on the Alzheimer disease Assessment Scale-cognitive subscale, …
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