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To the Editor:
I read with interest the article by Gordon-Lipkin et al.1 The authors studied a small heterogeneous group of patients with multiple sclerosis (MS) and gave no information concerning the presence of previous optic neuritis. They stated that “there were no selection biases based on history or severity of optic neuritis or MS characteristics.”
There are at least three possibilities: 1) all the patients had prior optic neuritis; 2) no patients had prior optic neuritis; or 3) the group is a mixture of patients with and without prior optic neuritis. According to the patients that have been included, the meanings of the results are different. The authors should have studied patients without prior optic neuritis to accurately conclude that there is a correlation between RNFL thickness and brain atrophy.
If all the patients …
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