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Patent foramen ovale (PFO) may be more frequent in the general population in the presence of migraine with aura than in subjects without migraine.1 Whether this association is causally related with migraine is not known. Studies have suggested that migraine is independently associated with PFO among stroke patients.1–3 Closure of PFO may be associated with disappearance of migraine attacks in patients who had a stroke, but none of these studies considered the natural evolution of migraine after a stroke.2,4–7 We evaluated changes in the frequency of migraine after the stroke event and before the PFO closure, at least 6 months after PFO closure, and at least 18 months after PFO closure.
Methods.
We included all patients who underwent a PFO closure at Bichat Hospital between January 2002 and April 2004; they were included if the indication of …
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