Quantification of neurometabolites in subacute sclerosing panencephalitis by 1H-MRS
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Abstract
The authors studied 20 patients with subacute sclerosing panencephalitis (SSPE) to investigate the correlations between MRI, magnetic resonance spectroscopy (MRS), and clinical status. MRI findings did not correlate with clinical status. By contrast, all patients had reductions in N-acetyl aspartate (NAA) and increase in myoinositol (mI) (p < 0.01), and NAA and mI concentrations correlated with clinical severity (p < 0.05). During follow-up, NAA continued to decline. 1H-MRS may be a useful measure of disease severity and progression in SSPE.
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Letters: Rapid online correspondence
- Quantification of neurometabolites in subacute sclerosing panencephalitis by 1H-MRS
- Banu Anlar, Hacettepe University, Dept of Pediatric Neurology, Ankara, Turkey 06100banlar@hacettepe.edu.tr
Submitted November 07, 2006 - Reply from the Authors
- Kubilay Aydin, Istanbul University, Istanbul Medical School, Department of Neuroradiology, Adnan Saygun Cad. M. Salihrustu bey sok. Ulus Konaklari, No: 8/12, Ulus, Istanbul , Turkeydr.aydink@superonline.com
Submitted November 07, 2006
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