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To the Editor:
We welcome the report by Honig et al.1 regarding a statistical association between intracranial atherosclerotic vascular disease (AVD) and Alzheimer disease (AD). The authors and readers would be interested to know that this work confirms our three previously-published studies.
Our first study examined 32 AD cases and compared them to 22 non-demented elderly controls.2 The circle of Willis was removed and atherosclerotic occlusion of the component arteries was assessed comprehensively using computerized image analysis. Arterial occlusion was significantly greater in the AD group than in the control group and there were significant correlations between mean arterial occlusion and both plaque and tangle density.
In our second study, we tested the association of intracranial AVD with AD in a larger series of cases.3 For this study, we compared circle of Willis AVD in …
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