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Abstract
The incidence of myasthenia gravis (MG) from 1970 through 1999 was studied in an area with 2.3 million inhabitants. The mean annual incidence rate of early-onset MG was constant at 3.5 × 10-6. In late-onset MG, the rate increased from 4.7 to 20.8 × 10-6. The two onset types of MG may thus be distinct disorders. The author hypothesized that late-onset nonthymoma anti–acetylcholine receptor antibody–seropositive MG may be provoked by environmental factors.
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