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Central neurogenic hyperventilation (CNH) is a rare disorder defined by sustained hyperventilation, characteristic findings on arterial blood gas analysis, and the absence of a peripheral respiratory stimulus.1 Although the mechanism of CNH has not been defined, elevation of CNS lactate concentration has been proposed as a possible cause.2 The syndrome has been described in a small number of patients with brainstem glioma and primary CNS lymphoma (PCNSL).1,3⇓ The presence of lactate within brain tumors is attributed to an anaerobic metabolic environment. On 1H magnetic resonance spectroscopy (MRS) lactate resonates at 1.2 to 1.5 ppm and is seen as an inverted doublet at echo time (TE) 144 msec.4 We report a patient with a brainstem glioma who developed CNH and whose MRS findings showed a new lactate peak within the tumor.
Case report.
A 25-year-old woman with typical clinical and radiographic findings suggesting the presence of a brainstem glioma developed CNH 3 weeks after …
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