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To the Editor:
We read with interest the article by Paradiso et al.1 The authors report the movement-related potentials recorded through electrodes for deep brain stimulation implanted in the subthalamic nucleus (STN) of patients with Parkinson disease “in the on state.” We agree with the notion of STN involvement in movement preparation, but we believe that the relationship between movement-related potentials (i.e., averaging) and previous findings obtained by frequency analysis (i.e., movement-related spectral changes) needs consideration.
First, frequency analysis shows a movement-related desynchronization in the beta range (20 to 30 Hz) starting before movement onset in the human STN not only off-medication,2,3⇓ but also on-medication.4 Movement-related beta desynchronization, therefore, contributes to the “involvement of the human subthalamic nucleus in movement preparation” in the on state. …
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