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The evaluation of transient neurologic spells when symptoms and deficits have resolved is challenging for the specialist and non-specialist alike.1,2⇓ Moreover, it has become clear that a TIA is not a benign condition. A TIA implies nothing less than is chemic stroke, and requires prompt diagnosis of etiology and initiation of secondary prevention because there is considerable risk of major stroke within the following 48 hours.3,4⇓
In the 1970s and 1980s, studies employing CT and conventional MR sequences suggested that a subgroup of patients with transient deficits had a relevant infarct on neuroimaging studies, although a temporal link could not be definitively established.5–7⇓⇓
The advent of clinical diffusion-weighted MRI (DWI) of acute stroke in the 1990s brought earlier and more sensitive diagnosis of ischemic lesions.8,9⇓ In the last few years, aggregate DWI data from seven prior studies, encompassing 288 patients, have clearly demonstrated that almost half of patients …
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