Advances in Neurology, Volume 85: Tourette Syndrome
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edited by D.J. Cohen, J. Jankovic, and C. Goetz,
400 pp., ill., Philadelphia, PA, Lippincott Williams & Wilkins, 2001, $169
Representing the proceedings of the 1999 Third International Symposium on Tourette syndrome (TS) held at the World Trade Center in New York City, this monograph showcases key advances in basic neurosciences, neuroimaging, genetics, clinical phenomenology, epidemiology, comorbidity and associated conditions, and treatment of TS. An important new section on immunology highlights pertinent features of group A β-hemolytic streptococcal (GABHS) infections, reviewing both evidence for and limitations to establishing a causal role for GABHS in triggering tics and obsessive compulsive symptoms.
This comprehensive textbook first reviews TS clinical phenomenology and phenotypes. Increased focus on characterizing and delineating meaningful clinical subtypes, such as the tic-related obsessive-compulsive disorder phenotype described in Chapter 4, has greatly enhanced current genetic and neurobiological research. Disentangling psychiatric comorbidity from TS phenotypic definition and treatment is discussed in Chapter 5’s excellent review of TS and attention deficit hyperactivity disorder (ADHD). A new chapter emphasizes autism spectrum disorders, a very challenging clinical population in whom tics, obsessional …
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