This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
To the Editor:
In a prospective clinicopathologic study of a population-based sample of 532 Finnish individuals (85 years or older), with neuropathologic examination in 118 of 198 deceased, Polvikoski et al.1 reported a prevalence of autopsy-confirmed AD of 33% as compared with 16% of clinically diagnosed AD. However, in the Rotterdam study, 27% of subjects at least age 85 were clinically classified as AD.2 Sixty-three percent of the Finnish APOE-ε4 carriers and 20% of noncarriers had autopsy-proven AD. These data indicating that the prevalence of definite AD in very old subjects is higher than previously reported, and that APOE genotype has a strong effect on the prevalence of AD, can only be confirmed in part by findings in a personal series of 170 autopsies of subjects (85 years or older) of the “Vienna Prospective Dementia Study,” in which subjects from nursing homes undergoing regular neurologic and neuropsychological evaluation came to neuropathologic examination between 1987 and 1999.
Sixty men and 59 women were under age 90; 11 men and 41 women were over age 90. The methods of recruitment, determination of cognitive status using Mini-Mental State Examination (MMSE) and DSM IIIR, criteria of the NINCDS-ADRDA for clinical diagnosis of AD, and neuropathologic …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
