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Fernandez–Arquero et al.1 reported that a promoter region polymorphism in the tumor necrosis factor α gene, TNFA-376A, was associated with susceptibility to MS in Spain. We previously performed a comprehensive screen of the promoter region, all exons, and their splice junction regions of TNFA2 and reported no association of the TNFA-308 polymorphism with MS.3 Our screen began at position −353 in the promoter region; therefore, we did not identify the TNFA-376A variant, which is just 5′ to the sequence that we screened. We evaluated the findings of Fernandez–Arquero et al.1 in our population.
Methods.
We studied the putative association of this …
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