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To the Editor:
We read with interest the correspondences by Sriram1 and Boman et al.2 concerning the matter of Chlamydia pneumoniae in the central nervous system of patients with MS. Boman et al.3 previously reported the failure to detect C. pneumoniae in the CNS of patients with MS. They also reported that some group might detect C. pneumoniae DNA in the CSF of patients with MS, if the CSF contains circulating white blood cells.2
Layh–Schmitt et al.4 reported that they identified C. pneumoniae in CSF by PCR in MS. Their conclusion is in general agreement with previous studies, but their rate of positive results is lower than in a recent report.4,5⇓
C. pneumoniae is a common etiologic agent that causes acute infection in the respiratory tract. Chlamydial infections are known to become chronic or persistent. However, the clinical spectrum of C. pneumoniae infection other than acute respiratory tract infection has not been completely clarified.6
There is evidence indicating that C. pneumoniae might play an etiologic …
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