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Benzodiazepines are the treatment of choice for management of acute seizures.1 In an effort to provide a reliable, safe, and effective in-home treatment for acute repetitive seizures (ARS) by caregivers, a rectal gel formulation of diazepam (Diastat; DST) was developed that provides rapid, consistent absorption.2
DST, dosed according to age and weight (age 2 to 5 years, 0.5 mg/kg; age 6 to 11 years, 0.3 mg/kg; age 12 years and older, 0.2 mg/kg), significantly reduced the frequency of seizures and increased the interval until the next seizure in two double-blind placebo-controlled studies.3,4⇓ A third open-label extension study was available to patients from the previous two studies who had stable antiepileptic drug regimens yet periodically experienced ARS episodes.
We describe the safety of DST in patients who received this formulation in excess of that recommended in the study protocol (>180%).
Patients and methods.
At the onset of each ARS …
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