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To the Editor:
Biraben et al.1 reported seven patients with juvenile myoclonic epilepsy (JME) myoclonus exacerbated by treatment with lamotrigine (LTG), four of whom were taking LTG monotherapy. As a result of this observation, they raised concerns about the rationale of using LTG in the treatment of JME.
Because of possible weight gain, hair loss, and menstrual irregularities with valproic acid (VPA) treatment,2 we have used LTG as a first-line therapy in women with JME. Our positive experience with the drug contrasts that reported by Biraben et al.
Retrospectively, 24 patients with an established diagnosis of JME were identified. Diagnosis was established by clinical history of sporadic generalized tonic-clonic (GTC) seizures, morning myoclonic jerks, and an EEG with generalized 3 to 4 Hz polyspike, slow-wave complexes. …
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