APOE ε2-4 and -491 polymorphisms are not associated with MS
Citation Manager Formats
Make Comment
See Comments
This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Several genes are likely to predispose to the pathologic changes of MS, but until recently the focus of the genetic search for linkage and associations has been primarily on genes coding for immunorelevant molecules. The factors able to foster the initial changes leading to CNS demyelination in MS patients remain unknown. Head injuries have been considered among them for their potential to open the blood–brain barrier and trigger CNS invasion by immunocytes and demyelination.
Apolipoprotein E (apoE) influences the high-affinity binding of low-density lipoproteins (LDL) to their receptor. This binding regulates the transport and metabolism of cholesterol and phospholipids, two of the major constituent myelin sheets. At least five polymorphisms have been reported in the APOE gene. The ε4 allele in the coding region has been associated with several degenerative neurologic diseases, including head trauma and AD.1-2 The recently described AA genotype of the -491 polymorphism in the promoter region3 provides a relative risk …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)
Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here
Purchase
Individual access to articles is available through the Add to Cart option on the article page. Access for 1 day (from the computer you are currently using) is US$ 39.00. Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means. The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use. Distributing copies (electronic or otherwise) of the article is not allowed.
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Dr. Dennis Bourdette and Dr. Lindsey Wooliscroft
► Watch
Related Articles
- No related articles found.
Alert Me
Recommended articles
-
Articles
APOE-ε2 allele associated with higher prevalence of sporadic Parkinson diseaseXuemei Huang, Peter C. Chen, Charles Poole et al.Neurology, June 21, 2004 -
Brief Communications
Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patientsF.L. Sciacca, C. Ferri, K. Vandenbroeck et al.Neurology, June 01, 1999 -
Articles
APOE epsilon variation in multiple sclerosis susceptibility and disease severitySome answersR. M. Burwick, P. P. Ramsay, J. L. Haines et al.Neurology, May 08, 2006 -
Articles
Apolipoprotein E-ε4 genotype predicts a poor outcome in survivors of traumatic brain injuryG. Friedman, P. Froom, L. Sazbon et al.Neurology, January 01, 1999