Infections as triggering factors for ischemic stroke
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Epidemiologic studies have identified several risk factors for ischemic stroke1-5 including hypertension, atherosclerosis, rheumatic and ischemic heart diseases, cardiac arrhythmias, and smoking. Nevertheless, a central question that has not been satisfactorily addressed, is what distinguishes people with these disorders who develop strokes from those who do not, and whether the occurrence of stroke is triggered by other factors. These factors could be environmental (such as climatic changes) or internal (for example, body temperature). Recently, several articles have pointed to the possibility that generalized inflammatory conditions might act as such triggers, particularly in the context of acute infections. These findings were supported by our own data. In a prospective study conducted by us, we attempted to study the frequency of preceding infections, compared with a control group consisting of patients who had undergone a stroke and were followed up at our stroke out-patient clinic. The results of this study have been published previously6 and will be reviewed here.
Methods. This study consisted of 182 consecutive patients (93 men) with ischemic strokes admitted to our hospital (figure 1). The diagnosis of ischemic stroke was made by experienced neurologists belonging to our stroke unit and confirmed in most cases by …
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