Should spinocerebellar ataxia type 5 be called Lincoln ataxia?
Citation Manager Formats
Make Comment
See Comments
![Loading Loading](https://n.neurology.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif)
This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
In the past few years, genetic characterization has assigned seven chromosomal loci-designated as spinocerebellar ataxia (SCA) types 1-5 (OMIM 164400, 183090, 183085, 600223, 600224), SCA type 7 (OMIM 164500), and dentatorubropallidoluysian atrophy (OMIM 125370)-to a group of dominantly inherited ataxias.1 The locus for a benign adult-onset form of dominantly inherited ataxia has been linked to the centromeric region of chromosome 11 in a family descended from the grandparents of President Abraham Lincoln.2 During our investigation of a family with dominantly inherited ataxia that has lived in Rockingham County, Virginia, since colonial times, we uncovered several interesting historical facts about President Lincoln's family that cast doubt that the SCA5 gene was inherited through the Lincoln lineage. As part of this investigation, we constructed a family pedigree of President Lincoln's ancestors based on several historical sources3-6(figure 1).
Figure 1. A partial pedigree of President Abraham Lincoln's family. Nine generations and 29 individuals from the president's family are shown. The names of family members whose signatures are found infigures 2 and 3 are followed by an asterisk (*). The known birth and death years are below each individual's name. Males are squares and females are circles. The dark symbols represent individuals with ataxia as cited by Ranum et al.2 The gray symbol representing individual VI-10 denotes that she had evidence of a tremor in her handwritten line.
Our 16th president's paternal grandfather, Captain Abraham Lincoln(individual VI-9, figure 1), was born in Berks County, Pennsylvania, on May 13, 1744, and later moved to northwest Virginia. Captain Lincoln was a wealthy landowner and a distinguished figure in the American militia during the Revolutionary War. His wife, Bathsheba (individual VI-10,figure 1), was born in Bridgewater, Virginia, …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)
Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here
Purchase
Individual access to articles is available through the Add to Cart option on the article page. Access for 1 day (from the computer you are currently using) is US$ 39.00. Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means. The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use. Distributing copies (electronic or otherwise) of the article is not allowed.
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Dr. Dennis Bourdette and Dr. Lindsey Wooliscroft
► Watch
Related Articles
- No related articles found.
Alert Me
Recommended articles
-
ARTICLES
Analysis of spinocerebellar ataxia type 1 (SCA1)-related CAG trinucleotide expansion in JapanT. Kameya, K. Abe, M. Aoki et al.Neurology, August 01, 1995 -
Editorials
Machado-Joseph disease and SCA3The genotype meets the phenotypesLarry Junck, John K. Fink et al.Neurology, January 01, 1996 -
Articles
Molecular and clinical analyses of spinocerebellar ataxia type 8 in JapanYoshio Ikeda, Masami Shizuka, Mitsunori Watanabe et al.Neurology, February 22, 2000 -
Articles
DNA analysis in hereditary dentatorubral-pallidoluysian atrophyCorrelation between CAG repeat length and phenotypic variation and the molecular basis of anticipationO. Komure, A. Sano, N. Nishino et al.Neurology, January 01, 1995