The Neurobiology of Central Nervous System Trauma
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edited by S.K. Salzman and A.I. Faden, 347 pp., ill., New York, Oxford University Press, 1994.
This reference work concerns the new field of neurotrauma. It came of age in 1990 when high doses of IV methylprednisolone were shown to control some of the pathobiology of human spinal cord injury. Methylprednisolone also controls brain edema, a common feature of poor outcomes from head trauma. Five chapters address the pathobiology and treatment of the three known types of brain edema (cytotoxic, vasogenic, ionic): Chapter 10 (``The Pathobiology of Traumatic Brain Injury''), Chapter 11 (``Ionic and Water Shifts in Injured Central Nervous Tissues''), Chapter 19 (``Astrocytic …
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