Abstract
Article abstract Seizures are a well-known manifestation of imipramine toxicity, but the pathophysiology of these seizures is unknown. Since myoclonic seizures can be generated in guinea pigs with 5-hydroxytryptophan, the precursor of serotonin, and since imipramine has been observed to decrease the reuptake to serotonin in the brain, an attempt was made to potentiate 5-hydroxytryptophan-induced myoclonus in guinea pigs with imipramine. Subthreshold doses of 5-hydroxytryptophan together with 35 mg per kilogram of imiparmine consistently led ?o myoclonic seizures in the animals. Antagonists of norepinephrine, dopamine, and acetylcholine all failed to block the potentiation of 5-hydroxytryptophan-induced seizures with imipramine. These results are consistent with the hypothesis that imiprarnine acts via serotonergic mechanisms in the brain to produce myoclonic seizures.
- © 1974 by the American Academy of Neurology
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
