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Half of all pregnancies in the United States are unplanned,1 and the average time of pregnancy recognition is at approximately 6 gestational weeks.2 Taken together, it is clear that some unintended fetal exposure to medications in early pregnancy is inevitable, particularly in populations with chronic illness where the use of medications is higher. Most medications have inadequate safety data during pregnancy,3 meaning that clinicians treating pregnant people must weigh clear benefits to the pregnant person against possible unknown safety concerns regarding the developing fetus. Understanding the safety of a medication depends on the appropriate selection of a comparison group receiving alternative treatment. Or, more succinctly: safety compared to what?
Footnotes
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
See page 60
- Received April 5, 2023.
- Accepted in final form April 14, 2023.
- © 2023 American Academy of Neurology
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