This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Sporadic Creutzfeldt-Jakob disease (sCJD) comprises approximately 85% of human prion diseases and is considered due to a post-translational modification of the native prion protein. Definitive diagnosis is only possible through neuropathologic examination at postmortem analysis or via an antemortem brain biopsy. Accurate and early clinical diagnosis of sCJD is important for patients and families, and to decrease the risk of iatrogenic transmission. Moreover, the low prevalence rate and rapid course of the illness hamper researchers' ability to perform clinical trials.
Probable sCJD is diagnosed after excluding all other possible causes and with the aid of EEGs and assays for detection of the 14-3-3 protein in CSF.1 However, both of these diagnostic tests have limitations, including low …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Topics Discussed
Alert Me
Recommended articles
High incidence of genetic human transmissible spongiform encephalopathies in Italy
Experimental transmission of Creutzfeldt-Jakob disease and related diseases to rodents
Evidence-based guideline: Diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease
Sporadic Creutzfeldt-Jakob disease mimicking nonconvulsive status epilepticus