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Abstract
Objective: To identify susceptibility loci for visual migraine aura in migraine families primarily affected with scintillating scotoma type of aura.
Methods: We included Finnish migraine families with at least 2 affected family members with scintillating scotoma as defined by the International Criteria for Headache Disorders–II. A total of 36 multigenerational families containing 351 individuals were included, 185 of whom have visual aura and 159 have scintillating scotoma. Parametric and nonparametric linkage analyses were performed with 378 microsatellite markers. The most promising linkage loci found were fine-mapped with additional microsatellite markers.
Results: A novel locus on chromosome 9q22-q31 for migraine aura was identified (HLOD = 4.7 at 104 cM). Fine-mapping identified a shared haplotype segment of 12 cM (9.8 Mb) on 9q21-q22 among the aura affecteds. Four other loci showed linkage to aura: a locus on 12p13 showed significant evidence of linkage, and suggestive evidence of linkage was detected to loci on chromosomes 5q13, 6q25, and 13q14.
Conclusions: A novel visual migraine aura locus has been mapped to chromosome 9q21-q22. Interestingly, this region has previously been linked to occipitotemporal lobe epilepsy with prominent visual symptoms. Our finding further supports a shared genetic background in migraine and epilepsy and suggests that susceptibility variant(s) to visual aura for both of these traits are located in the 9q21-q22 locus.
Glossary
- ASP=
- affected sibpairs;
- CSD=
- cortical spreading depression;
- FHM=
- familial hemiplegic migraine;
- GWA=
- genome-wide association;
- HLOD=
- lod score under locus heterogeneity;
- ICHD-II=
- International Classification of Headache Disorders, second edition;
- MA=
- migraine with aura;
- MO=
- migraine without aura;
- NPL=
- nonparametric linkage.
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