TY -的T1 -视觉先兆偏头痛轨迹映射到9 q21-q22 JF -神经学乔-神经病学SP - 1171 LP - 1177 - 首页10.1212 / WNL。0 b013e3181d8ffcb六世- 74 - 15 AU - p . Tikka-Kleemola盟诉Artto E.M.索贝尔盟- s Vepsalainen盟盟- s Raty AU -硕士Kaunisto盟诉安提拉AU - e . Hamalainen AU - >。Sumelahti AU - m . Ilmavirta AU - m . Farkkila AU - m . Kallela AU - a . Palotie盟m . Wessman Y1 - 2010/04/13 UR - http://n.首页neurology.org/content/74/15/1171.abstract N2 -目的:识别易感性位点为视觉偏头痛先兆偏头痛家庭主要影响与闪烁的暗点类型的光环。方法:我们包括芬兰偏头痛有至少2影响家庭成员的家庭与闪烁的暗点作为头痛Disorders-II国际标准定义的。36代家庭包括包含351人,185人有视觉先兆和159有闪烁的暗点。参数和非参数连锁分析378个微卫星标记。最有前途的连锁位点发现fine-mapped有额外的微卫星标记。结果:小说轨迹对染色体9 q22-q31先兆偏头痛被确定在104厘米(HLOD = 4.7)。精细定位确定共享单体型段12厘米(9.8 Mb) 9日q21-q22光环的影响。其他四个位点光环显示链接:p13 12日轨迹显示链接的重要证据,发现和启发性的证据的链接对染色体位点5问题,6 q25, 13 q14。 Conclusions: A novel visual migraine aura locus has been mapped to chromosome 9q21-q22. Interestingly, this region has previously been linked to occipitotemporal lobe epilepsy with prominent visual symptoms. Our finding further supports a shared genetic background in migraine and epilepsy and suggests that susceptibility variant(s) to visual aura for both of these traits are located in the 9q21-q22 locus. ASP=affected sibpairs; CSD=cortical spreading depression; FHM=familial hemiplegic migraine; GWA=genome-wide association; HLOD=lod score under locus heterogeneity; ICHD-II=International Classification of Headache Disorders, second edition; MA=migraine with aura; MO=migraine without aura; NPL=nonparametric linkage. ER -