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There are no neuroses, only neurotics. This notion, expressed more than 50 years ago by Kurt Schneider,1 conceives “neuroticism” as an abiding tendency toward negative affective reaction, e.g., depression or anxiety, in stressful circumstances. The idea traces back at least to Eysenck2 and Slater,3 who explored the relation of emotional vulnerability and cognitive abilities.
This issue of Neurology includes a report by Wilson et al.4 from the Religious Orders Study, a longitudinal clinicopathologic investigation of Alzheimer’s disease (AD) in older Catholic nuns, priests, and brothers. The authors’ term “distress-proneness” is less subject to misinterpretation but is otherwise equivalent to neuroticism. They measured the trait using the Neuroticism (N) scale from the NEO Five-Factor Inventory,5 an extensively validated assessment of variation in personality. They considered N scores among many variables in a sample of 797 persons with one or more (mean, 5.9) …
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