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Behavioral disturbance is common and costly in AD. The occurrence of psychiatric symptoms is strongly correlated with carer stress and institutionalization, but despite the increasing attention paid to what is now often called Behavioural and Psychological Symptoms in Dementia (BPSD), little is known as to why these symptoms affect only some patients. One possible factor is a genetic one. Previously certain BPSD including agitation, depression, and psychosis were shown to aggregate in affected siblings in AD and also in Huntington disease.1,2⇓ Now Bacanu et al.3 have taken these studies one step further by combining the genotype data from the genome wide linkage study performed on the National Institute of Mental Health AD genetics initiative sample4,5⇓ with clinical data. Affected siblings sharing BPSD (in this case psychosis) show possible linkage to three loci—one each on chromosomes 2, 6, and 21.3
One interpretation of these data, and the one favored …
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