This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Benzodiazepines are the treatment of choice for management of acute seizures.1 In an effort to provide a reliable, safe, and effective in-home treatment for acute repetitive seizures (ARS) by caregivers, a rectal gel formulation of diazepam (Diastat; DST) was developed that provides rapid, consistent absorption.2
DST, dosed according to age and weight (age 2 to 5 years, 0.5 mg/kg; age 6 to 11 years, 0.3 mg/kg; age 12 years and older, 0.2 mg/kg), significantly reduced the frequency of seizures and increased the interval until the next seizure in two double-blind placebo-controlled studies.3,4⇓ A third open-label extension study was available to patients from the previous two studies who had stable antiepileptic drug regimens yet periodically experienced ARS episodes.
We describe the safety of DST in patients who received this formulation in excess of that recommended in the study protocol (>180%).
Patients and methods.
At the onset of each ARS …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Costs and Utilization of New-to-Market Neurologic Medications
Dr. Robert J. Fox and Dr. Mandy Leonard
► Watch
Alert Me
Recommended articles
Treating repetitive seizures with a rectal diazepam formulation
Respiratory adverse events associated with diazepam rectal gel
Parenteral antiepileptic/anticonvulsant drugs
Early Neurologic Recovery, Practice Pattern Variation, and the Risk of Endotracheal Intubation Following Established Status Epilepticus