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Since McArdle’s 1951 description1 of a man who did not produce lactate during ischemic forearm work, the ischemic exercise test is an established and widely used protocol to screen patients with suspected myopathies caused not only by defects of glycogen or glucose metabolism but also by myoadenylate deaminase deficiency, failing to show an increase of ammonia in the latter. Usually patients with these disorders complain of cramps and myalgia during and after the test. There is only one report in which massive myoglobinemia and myoglobinuria developed subsequent to the test in a patient with McArdle’s disease.2 Until now no other dangerous side effects of this test have been described. Here we describe a rare case of McArdle’s disease in which acute compartment syndrome of the left forearm developed subsequent to the ischemic forearm test.
Case report.
A 22-year-old woman had weakness and rapid fatigue of her leg and arm muscles as well as intermittent claudicatio-like cramps in her forearms after physical exertion. These complaints were first noted at age 8. There was no history …
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