Infection, inflammation, and cerebrovascular ischemia
Citation Manager Formats
Make Comment
See Comments
![Loading Loading](https://n.neurology.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif)
This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Hemostatic and inflammatory pathways mutually interact with each other. Increased inflammatory parameters are a sequel of and also a risk factor for cerebral thrombosis and ischemia. Ischemic stroke is followed by an acute-phase response that is characterized by a transient rise in fibrinogen, leukocyte count, and several cytokines. This article focuses on inflammatory changes that precede cerebral ischemia and on inflammation/infection as a risk factor for stroke and transient ischemic attack (TIA).
Inflammatory parameters and vascular diseases and risk factors. The leukocyte count is positively associated with the risk for ischemic stroke and myocardial infarction.1,2 The granulocyte count appears to contribute mainly to such elevated risk. A recent epidemiologic study found that the monocyte count also correlated with an increased risk for myocardial ischemia.3 High plasma fibrinogen levels are a risk factor for stroke and myocardial infarction(MI).4 Moreover, several serum glycoproteins, mostly acute-phase reactants, were shown to be correlated with the severity of coronary atherosclerosis.5
Although the above inflammatory parameters appear to independently predict the risk of ischemic diseases, several vascular risk factors are themselves correlated with an increase in inflammatory parameters. We studied the association of leukocyte count, fibrinogen, and C-reactive protein (CRP) with vascular risk factors in the control group of our recent case-control study investigating acute infection as a risk factor for stroke.6,7 These control subjects were randomly selected from the population and were matched to stroke patients for sex and age. Subjects with the following conditions were excluded from the analysis: malignancies, acute or chronic inflammatory diseases; recent trauma, surgery, and vascular diseases.
In an ANOVA model with several risk factors and ischemic diseases, diabetes mellitus was associated with higher leukocyte count, fibrinogen and CRP. High age was correlated with increased leukocyte count and fibrinogen; Smoking and a history of stroke …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)
Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here
Purchase
Individual access to articles is available through the Add to Cart option on the article page. Access for 1 day (from the computer you are currently using) is US$ 39.00. Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means. The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use. Distributing copies (electronic or otherwise) of the article is not allowed.
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Dr. Jessica Ailani and Dr. Ailna Masters-Israilov
► Watch
Related Articles
- No related articles found.
Alert Me
Recommended articles
-
Articles
Recent bacterial and viral infection is a risk factor for cerebrovascular ischemiaClinical and biochemical studiesA. J. Grau, F. Buggle, H. Becher et al.Neurology, January 01, 1998 -
Articles
Renal dysfunction and risk of ischemic stroke or TIA in patients with cardiovascular diseaseNira Koren-Morag, Uri Goldbourt, David Tanne et al.Neurology, July 24, 2006 -
Articles
Lipid levels and the risk of ischemic stroke in womenT. Kurth, B. M. Everett, J. E. Buring et al.Neurology, February 19, 2007 -
Article
HIV status and the risk of ischemic stroke among menJason J. Sico, Chung-Chou H. Chang, Kaku So-Armah et al.Neurology, April 10, 2015