This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
We read with interest the results of this randomized clinical trial, which shows that normobaric hyperoxia combined with endovascular treatment is safe, could reduce infarct volume, and improve clinical outcomes in patients with acute ischemic stroke compared with patients who received only endovascular treatment.1 The authors are to be commended on successfully leveraging such a pragmatic treatment. It is of importance that these findings stand in stark contrast to the Stroke Oxygen Study, which found no benefit of supplemental oxygen (2–3 L/min) in patients with acute stroke.2 While there were no consistent effects of hyperoxemia across exploratory subgroups of the 8,003 patients in the Stroke Oxygen trial, including the subgroup with acute ischemic stroke (n = 6,334), there was a trend suggesting benefit of hyperoxia in patients with more severe deficits, which indicates possible acute large vessel occlusion. Patients with a baseline NIHSS of 15–20 were nonsignificantly at greater odds of achieving a better 90-day functional outcome with supplemental oxygen (OR 1.28, 95% CI 0.94–1.73) when compared with patients with lower NIHSS (e.g., NIHSS 0–4 OR 0.94, 95% CI 0.83–1.07).
Footnotes
Author disclosures are available upon request (journal{at}neurology.org).
- Received October 6, 2022.
- Accepted in final form October 6, 2022.
- © 2022 American Academy of Neurology
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
