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We thank Drs. Schiele and Chopard for their comment on our article.1 We did not collect specific information on statin use in the current study. We, thus, cannot examine whether statin use was associated with altered risk of intracerebral hemorrhage (ICH). However, usage of statins was uncommon in 2006—baseline of the Kailuan Study—in China. For example, in the PURE-China Study, which enrolled 45,108 individuals between 2005 and 2009 from 70 rural and 45 urban communities in 12 provinces of China, only 1.7% participants with cardiovascular diseases reported taking statins.2 Published studies regarding the relationship between statin use and ICH generated inconsistent results. For example, although the aforementioned Danish study reported an association between statin use and low ICH risk, a meta-analysis of statin clinical trials including 174,149 participants reported a trend between statin use and a high ICH risk (pooled relative risk 1.14 for per 1.0-mmol/L LDL-C reduction, 95% CI 0.96–1.36).3 Thus, more studies are warranted to understand a relationship between lipid-lowering medication use and risk of ICH.
Footnotes
Author disclosures are available upon request (journal{at}neurology.org).
- © 2020 American Academy of Neurology
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