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Abstract
Objective To determine whether intranasal oxytocin, alone or in combination with instructed mimicry of facial expressions, would augment neural activity in patients with frontotemporal dementia (FTD) in brain regions associated with empathy, emotion processing, and the simulation network, as indexed by blood oxygen–level dependent (BOLD) signal during fMRI.
Methods In a placebo-controlled, randomized crossover design, 28 patients with FTD received 72 IU intranasal oxytocin or placebo and then completed an fMRI facial expression mimicry task.
Results Oxytocin alone and in combination with instructed mimicry increased activity in regions of the simulation network and in limbic regions associated with emotional expression processing.
Conclusions The findings demonstrate latent capacity to augment neural activity in affected limbic and other frontal and temporal regions during social cognition in patients with FTD, and support the promise and need for further investigation of these interventions as therapeutics in FTD.
ClinicalTrials.gov identifier NCT01937013.
Classification of evidence This study provides Class III evidence that a single dose of 72 IU intranasal oxytocin augments BOLD signal in patients with FTD during viewing of emotional facial expressions.
Glossary
- ACC=
- anterior cingulate cortex;
- ANCOVA=
- analysis of covariance;
- AFNI=
- Analysis of Functional NeuroImages;
- BOLD=
- blood oxygen–level dependent;
- bvFTD=
- behavioral variant FTD;
- FD=
- framewise displacement;
- FOXY=
- Intranasal Oxytocin for Frontotemporal Dementia;
- FTD=
- frontotemporal dementia;
- FWE=
- family-wise error;
- IFG=
- inferior frontal gyrus;
- IPL=
- inferior parietal lobule;
- MET=
- Multifaceted Empathy Test;
- NEM=
- nonemotional movement;
- PFC=
- prefrontal cortex;
- PKT=
- Postural Knowledge Test;
- PMC=
- premotor cortex;
- SMA=
- supplementary motor area;
- STS=
- superior temporal sulcus
Footnotes
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
Editorial, page 849
Class of Evidence: NPub.org/coe
- Received April 13, 2020.
- Accepted in final form July 14, 2020.
- © 2020 American Academy of Neurology
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