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Accurate genetic diagnosis in inherited muscle diseases is challenging, with over 30 causative genes for the limb-girdle muscular dystrophies (LGMDs) alone,1 but also vital, with gene-specific therapies now available and more on the horizon.2 Although next-generation sequencing provides a wealth of genetic data, interpretation often requires deep phenotyping including clinical, laboratory, and imaging data. Many MRI studies have described the different patterns of muscle involvement in inherited muscle diseases.3 Whereas the MRI patterns are generally concordant with the clinical distribution of weakness, using MRI patterns of involvement potentially offers greater complexity and discrimination because of the ability to assess each muscle individually.
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