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Identifying mechanisms of neurodegenerative disease causation seemed to be beyond the pale of traditional epidemiologic tools. Elucidating a plausible mechanism for initiation of amyotrophic lateral sclerosis (ALS) appeared particularly elusive.1 The principal barrier to discerning ALS pathogenesis was the need to conceptualize ALS correctly2: an active process, initiated in cortical motor neurons, that dismantles the human motor neuronal supernetwork systematically.1
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- © 2019 American Academy of Neurology
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