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Low-density lipoprotein (LDL) is sensitive to oxidative injury, and oxidized LDL (oxLDL) represents the major modified form of native LDL. There is evidence of the role of oxLDL in the initiation of atherosclerosis and its progression, plaque rupture, and thus cardiovascular diseases.1 This study evaluated the association between oxLDL levels and stroke recurrence in 3,019 patients with minor stroke or TIA included in the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) trial.2 Overall, the study was properly conducted, although the oxLDL-4E6 antibody, which has potential cross-reactivity with native LDL and cannot detect oxLDL with <60 lysine modifications, was used for the determination of circulating oxLDL levels.
Footnotes
See page 442
Financial Disclosures: Dr. Lorenzano served as expert consultant for Boehringer Ingelheim and has received travel funding from Boehringer Ingelheim, Quintiles IMS, Bayer, and Daichii Sankyo. Go to Neurology.org/N for full disclosures.
Study Funding: No targeted funding reported.
- Received July 2, 2018.
- Accepted in final form July 3, 2018.
- © 2018 American Academy of Neurology
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