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The article by Tsivgoulis et al.1 focused on the potential effect of statin pretreatment on outcomes in patients with large artery atherosclerosis. We conducted 2 relevant exploratory analyses based on data from the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial, in which patients with noncardioembolic stroke were randomized to high-dose atorvastatin (80 mg/day) or placebo.2 In the first, we hypothesized that the …
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